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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HLTF All Species: 36.06
Human Site: S884 Identified Species: 61.03
UniProt: Q14527 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14527 NP_003062.2 1009 113929 S884 V F T R L D G S M A Q K K R V
Chimpanzee Pan troglodytes XP_001138277 1009 113822 S884 V F T R L D G S M A Q K K R V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_534300 1106 124184 S981 V F T R L D G S M A Q K K R V
Cat Felis silvestris
Mouse Mus musculus Q6PCN7 1003 113298 S878 V F T R L D G S M A Q K K R V
Rat Rattus norvegicus NP_001099948 974 110023 S849 V F T R L D G S M A Q K K R V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508504 884 99044 K788 T I M L L S L K A G G V G L N
Chicken Gallus gallus
Frog Xenopus laevis NP_001090145 999 112576 S874 M F T R L D G S M T Q K K R T
Zebra Danio Brachydanio rerio XP_693071 942 104740 S819 S F T R L D G S L I Q R A R A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P34739 1061 118357 T941 A T L S L N G T I P V K N R Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786706 1093 121576 S963 K F C R L D G S M S R I A R T
Poplar Tree Populus trichocarpa XP_002308876 799 88908 S703 G P T V L L A S L K A S G A G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FF61 881 98598 S785 G P V V L L A S L K A S G T G
Baker's Yeast Sacchar. cerevisiae P31244 790 91412 V694 I Q C E V F L V S L K A G G V
Red Bread Mold Neurospora crassa Q7S1P9 1222 137173 S1101 S F L R L D G S M S Q K A R A
Conservation
Percent
Protein Identity: 100 99.5 N.A. 85.5 N.A. 83.6 81.4 N.A. 71.7 N.A. 64.3 53.1 N.A. 21.1 N.A. N.A. 34.5
Protein Similarity: 100 99.8 N.A. 88 N.A. 89.7 87.9 N.A. 78.5 N.A. 79.3 69.8 N.A. 41.2 N.A. N.A. 53.1
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 6.6 N.A. 80 60 N.A. 26.6 N.A. N.A. 53.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 6.6 N.A. 86.6 73.3 N.A. 46.6 N.A. N.A. 66.6
Percent
Protein Identity: 33.6 N.A. N.A. 36 22.7 25.2
Protein Similarity: 50.4 N.A. N.A. 52.7 40.9 43.9
P-Site Identity: 20 N.A. N.A. 13.3 6.6 66.6
P-Site Similarity: 26.6 N.A. N.A. 20 26.6 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 15 0 8 36 15 8 22 8 15 % A
% Cys: 0 0 15 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 65 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 65 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 15 0 0 0 0 0 72 0 0 8 8 0 29 8 15 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 8 0 0 0 0 0 0 8 8 0 8 0 0 0 % I
% Lys: 8 0 0 0 0 0 0 8 0 15 8 58 43 0 0 % K
% Leu: 0 0 15 8 93 15 15 0 22 8 0 0 0 8 0 % L
% Met: 8 0 8 0 0 0 0 0 58 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 0 0 0 0 0 8 0 8 % N
% Pro: 0 15 0 0 0 0 0 0 0 8 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 0 0 0 0 0 58 0 0 0 8 % Q
% Arg: 0 0 0 65 0 0 0 0 0 0 8 8 0 72 0 % R
% Ser: 15 0 0 8 0 8 0 79 8 15 0 15 0 0 0 % S
% Thr: 8 8 58 0 0 0 0 8 0 8 0 0 0 8 15 % T
% Val: 36 0 8 15 8 0 0 8 0 0 8 8 0 0 43 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _